SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                                (Amendment No. 8)

                   Under the Securities Exchange Act of 1934*

                             Nabi Biopharmaceuticals
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                     Common Stock, par value $0.10 per share
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    629519109
- --------------------------------------------------------------------------------
                      (CUSIP Number of Class of Securities)

                                 Daniel S. Loeb
                                 Third Point LLC
                                 390 Park Avenue
                               New York, NY 10022
                                 (212) 224-7400
- --------------------------------------------------------------------------------
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                   Copies to:
                            Michael A. Schwartz, Esq.
                          Willkie Farr & Gallagher LLP
                               787 Seventh Avenue
                             New York, NY 10019-6099
                                 (212) 728-8000

                                October 16, 2006
- --------------------------------------------------------------------------------
                          (Date of Event which Requires
                            Filing of this Schedule)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of ss.ss. 240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the
following box: [ ]

NOTE: Schedules filed in paper format shall include a signed original and five
copies of the schedule, including all exhibits. See Rule 240.13d-7 for other
parties to whom copies are to be sent.

* The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).





                                  SCHEDULE 13D


- ----------------------------------                             -----------------
CUSIP No. 629519109                                            Page 2 of 7 Pages
- ----------------------------------                             -----------------


- ----------- --------------------------------------------------------------------
    1       NAME OF REPORTING PERSON
            I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

            Third Point LLC                                 I.D. #13-3922602
- ----------- --------------------------------------------------------------------
    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a) [ ]
                                                                      (b) [X]

- ----------- --------------------------------------------------------------------
    3       SEC USE ONLY

- ----------- --------------------------------------------------------------------
    4       SOURCE OF FUNDS*

            AF
- ----------- --------------------------------------------------------------------
    5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
            PURSUANT TO ITEMS 2(d) or 2(e)                                [ ]

- ----------- --------------------------------------------------------------------
    6       CITIZENSHIP OR PLACE OF ORGANIZATION

            Delaware
- --------------------- --------- ------------------------------------------------
                         7      SOLE VOTING POWER

                                0
                      --------- ------------------------------------------------
NUMBER OF                8      SHARED VOTING POWER
SHARES
BENEFICIALLY                    5,750,000
OWNED BY              --------- ------------------------------------------------
EACH                     9      SOLE DISPOSITIVE POWER
REPORTING
PERSON WITH                     0
                      --------- ------------------------------------------------
                         10     SHARED DISPOSITIVE POWER

                                5,750,000
- ----------- --------------------------------------------------------------------
    11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

            5,750,000
- ----------- --------------------------------------------------------------------
    12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
            CERTAIN SHARES*                                               [ ]

- ----------- --------------------------------------------------------------------
    13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

            9.5%
- ----------- --------------------------------------------------------------------
    14      TYPE OF REPORTING PERSON*

            OO
- ----------- --------------------------------------------------------------------





                                  SCHEDULE 13D


- ----------------------------------                             -----------------
CUSIP No. 629519109                                            Page 3 of 7 Pages
- ----------------------------------                             -----------------


- ----------- --------------------------------------------------------------------
    1       NAME OF REPORTING PERSON
            I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

            Third Point Offshore Fund, Ltd.
- ----------- --------------------------------------------------------------------
    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a) [ ]
                                                                      (b) [X]

- ----------- --------------------------------------------------------------------
    3       SEC USE ONLY

- ----------- --------------------------------------------------------------------
    4       SOURCE OF FUNDS*

            AF
- ----------- --------------------------------------------------------------------
    5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
            PURSUANT TO ITEMS 2(d) or 2(e)                                [ ]

- ----------- --------------------------------------------------------------------
    6       CITIZENSHIP OR PLACE OF ORGANIZATION

            Cayman Islands
- --------------------- --------- ------------------------------------------------
                         7      SOLE VOTING POWER

                                0
                      --------- ------------------------------------------------
NUMBER OF                8      SHARED VOTING POWER
SHARES
BENEFICIALLY                    3,724,100
OWNED BY              --------- ------------------------------------------------
EACH                     9      SOLE DISPOSITIVE POWER
REPORTING
PERSON WITH                     0
                      --------- ------------------------------------------------
                         10     SHARED DISPOSITIVE POWER

                                3,724,100
- ----------- --------------------------------------------------------------------
    11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

            3,724,100
- ----------- --------------------------------------------------------------------
    12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
            CERTAIN SHARES*                                               [ ]

- ----------- --------------------------------------------------------------------
    13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

            6.2%
- ----------- --------------------------------------------------------------------
    14      TYPE OF REPORTING PERSON*

            OO
- ----------- --------------------------------------------------------------------





                                  SCHEDULE 13D


- ----------------------------------                             -----------------
CUSIP No. 629519109                                            Page 4 of 7 Pages
- ----------------------------------                             -----------------


- ----------- --------------------------------------------------------------------
    1       NAME OF REPORTING PERSON
            I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

            Daniel S. Loeb
- ----------- --------------------------------------------------------------------
    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP          (a) [ ]
                                                                      (b) [X]

- ----------- --------------------------------------------------------------------
    3       SEC USE ONLY

- ----------- --------------------------------------------------------------------
    4       SOURCE OF FUNDS*

            AF
- ----------- --------------------------------------------------------------------
    5       CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDING IS REQUIRED
            PURSUANT TO ITEMS 2(d) or 2(e)                                [ ]

- ----------- --------------------------------------------------------------------
    6       CITIZENSHIP OR PLACE OF ORGANIZATION

            United States
- --------------------- --------- ------------------------------------------------
                         7      SOLE VOTING POWER

                                0
                      --------- ------------------------------------------------
NUMBER OF                8      SHARED VOTING POWER
SHARES
BENEFICIALLY                    5,750,000
OWNED BY              --------- ------------------------------------------------
EACH                     9      SOLE DISPOSITIVE POWER
REPORTING
PERSON WITH                     0
                      --------- ------------------------------------------------
                         10     SHARED DISPOSITIVE POWER

                                5,750,000
- ----------- --------------------------------------------------------------------
    11      AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH PERSON

            5,750,000
- ----------- --------------------------------------------------------------------
    12      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES
            CERTAIN SHARES*                                               [ ]

- ----------- --------------------------------------------------------------------
    13      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

            9.5%
- ----------- --------------------------------------------------------------------
    14      TYPE OF REPORTING PERSON*

            IN
- ----------- --------------------------------------------------------------------





     This Amendment No. 8 (the "Amendment") amends the Schedule 13D filed on
April 17, 2006 (together with Amendment No. 1 thereto previously filed on April
27, 2006, Amendment No. 2 thereto previously filed on June 15, 2006, Amendment
No. 3 thereto previously filed on August 16, 2006, Amendment No. 4 thereto
previously filed on September 5, 2006, Amendment No. 5 thereto previously filed
on September 14, 2006, Amendment No. 6 thereto previously filed on September 26,
2006 and Amendment No. 7 thereto previously filed on October 4, 2006, the
"Schedule 13D") and is being filed on behalf of Third Point LLC, a Delaware
limited liability company (the "Management Company"), Third Point Offshore Fund,
Ltd., a Cayman Islands limited liability exempted company (the "Offshore Fund"),
and Daniel S. Loeb, an individual ("Mr. Loeb" and, together with the Management
Company and the Offshore Fund, the "Reporting Persons"). Unless the context
otherwise requires, references herein to the "Common Stock" are to shares of
common stock, par value $0.10 per share, of Nabi Biopharmaceuticals, a Delaware
corporation (the "Company"). The Management Company is the investment manager or
adviser to a variety of hedge funds and managed accounts (such funds and
accounts, collectively, including but not limited to the Offshore Fund, the
"Funds"). The Funds directly own the Common Stock to which this Schedule 13D
relates, and the Reporting Persons may be deemed to have beneficial ownership
over such Common Stock by virtue of their ownership or the authority granted to
them by the Funds to vote and to dispose of the securities held by the Funds,
including the Common Stock.


Item 4.  Purpose of Transaction.

     Item 4 of the Schedule 13D is hereby amended by adding the following
thereto:

     On October 16, 2006, the Reporting Persons sent a letter to the Board of
Directors in response to the Company's announcement of the sale of its PhosLo
product and the subsequent conference call conducted by the Company.

     A copy of the letter to the company is filed herewith as Exhibit 99.1 and
is incorporated herein by reference in its entirety.

                                     * * * *

     In connection with the consent solicitation, Third Point LLC and certain of
its affiliates intend to file a consent statement with the Securities and
Exchange Commission (the "SEC") to solicit stockholders of the Company with
respect to the removal





of Mr. McLain and possibly one or more other directors from the Board of
Directors. THIRD POINT LLC STRONGLY ADVISES ALL STOCKHOLDERS OF THE COMPANY TO
READ THE CONSENT STATEMENT WHEN IT BECOMES AVAILABLE BECAUSE IT WILL CONTAIN
IMPORTANT INFORMATION, INCLUDING INFORMATION RELATING TO THE PARTICIPANTS IN ANY
SUCH CONSENT SOLICITATION. SUCH CONSENT STATEMENT, WHEN FILED, AND ANY OTHER
RELEVANT DOCUMENTS WILL BE AVAILABLE AT NO CHARGE ON THE SEC'S WEBSITE AT
HTTP://WWW.SEC.GOV.

THIRD POINT PARTICIPANT INFORMATION

     In accordance with Rule 14a-12(a)(1)(i) of the Securities Exchange Act of
1934, as amended, the following persons are anticipated to be, or may be deemed
to be, participants in any such consent solicitation by Third Point LLC: Third
Point LLC, Mr. Loeb, Third Point Offshore Fund, Ltd., Third Point Ultra Ltd.,
Third Point Partners LP, Third Point Partners Qualified LP and Lyxor/Third Point
Fund Limited. Certain of these persons hold direct or indirect interests as
follows: Third Point LLC may be deemed to beneficially own 5,750,000 shares of
Common Stock; Mr. Daniel Loeb may be deemed to own 5,750,000 shares of Common
Stock; Third Point Offshore Fund, Ltd. may be deemed to beneficially own
3,724,100 shares of Common Stock; Third Point Ultra Ltd. may be deemed to
beneficially own 614,300 shares of Common Stock; Third Point Partners LP may be
deemed to beneficially own 585,300 shares of Common Stock; Third Point Partners
Qualified LP may be deemed to beneficially own 459,100 shares of Common Stock;
and Lyxor/Third Point Fund Limited may be deemed to beneficially own 367,200
shares of Common Stock.



Item 7.  Material to be Filed as Exhibits.

     99.1 Letter, dated October 16, 2006, from the Management Company to the
Company.





                                   SIGNATURES

     After reasonable inquiry and to the best of our knowledge and belief, the
undersigned certify that the information set forth in this statement is true,
complete and correct.


Dated: October 16, 2006


                                             THIRD POINT LLC



                                             By: /s/ Daniel S. Loeb
                                                 -------------------------------
                                                 Name:   Daniel S. Loeb
                                                 Title:  Chief Executive Officer



                                             THIRD POINT OFFSHORE FUND, LTD.



                                             By: /s/ Daniel S. Loeb
                                                 -------------------------------
                                                 Name:   Daniel S. Loeb
                                                 Title:  Director





                                             /s/ Daniel S. Loeb
                                             -----------------------------------
                                             Daniel S. Loeb



               [SIGNATURE PAGE TO AMENDMENT NO. 8 TO SCHEDULE 13D
                    WITH RESPECT TO NABI BIOPHARMACEUTICALS]
                           Third Point LLC Letterhead

Sent via overnight mail

October 16, 2006

Dear Nabi Directors:

As you are probably aware, on October 12th Nabi Biopharmaceuticals (the
"Company") held a conference call following the announcement of the sale of
PhosLo to Fresenius. In that call, Tom McLain articulated a plan which, when
stripped down to its essence, would use the sale proceeds to fund $30 million
per annum of cash burn in 2007 and 2008. Thus, the Company has proven our thesis
that it contains valuable and coveted assets. The net present value of the
PhosLo sale, which was exactly in line with our estimates, confirms our view
that Nabi's assets are worth roughly twice as much as where the stock currently
trades.

However, the conference call also confirmed our fears that this management and
Board are prepared to dissipate asset sale proceeds on a risky business strategy
rather than return them to shareholders. Further confirmation came in your
letter to shareholders this morning, which stated that the proceeds from the
sale of PhosLo, from partnering NicVAX and StaphVAX and Civacir, and the
associated expected cost reductions will be used "to fund ... important
development programs." Your strategy may now be clear, but we are baffled as to
which "important development programs" you intend to fund going forward.

We have repeatedly warned this Board that we (and, we are confident, other
shareholders) will not tolerate a "burning the furniture to heat the house"
policy with respect to asset sales and spending, which is precisely the policy
your October 12 conference call and this morning's letter appear to adopt.
Indeed, there is no conceivable reason why Nabi should be in a cash burn
position once the PhosLo disposition has been consummated and the major
development projects sold or partnered. In fact, if the Company were to become
an efficiently-run ongoing entity after such a restructuring, it should be
earnings and cash-flow positive by mid-2007.

Mr. McLain unwittingly gave one of the most persuasive arguments on the
conference call as to why Nabi should not continue as a public company. When
asked about the cash flows from Nabi-HB, and why they would not be sufficient to
fund ongoing business spending, he responded that this cash flow will be offset
by the costs of being a public company. While we can't begin to fathom why it
would cost nearly that much to run Nabi as a public company (given Nabi-HB's
approximately $40 million in annual sales and the fact that the related cash
flows should be a very high percentage of its sales), Mr. McLain's answer makes
our point seem obvious - Nabi should NOT be a public company. We believe that
Nabi-HB is worth upwards of $200 million, and the Company can get no credit for
that substantial value in the marketplace if this value is in effect negated by
unfathomable overhead and "development" expenses.





As you know, last month we proposed a settlement whereby we would place
representatives on the Board to help ensure the success of the
value-maximization process for all shareholders and ensure that shareholders
directly receive the proceeds from any asset sales - as well as to aid in
immediately beginning to mitigate Nabi's unnecessary cash burn. Unfortunately,
your response made it clear that you have no interest in engaging in earnest
discussions to involve the Company's highly-qualified owners in the oversight of
these issues.

Accordingly, you have left us no choice: we have now determined to pursue a
consent solicitation to remove not only McLain but, as well, a majority of the
Company's directors from the Board. Concurrently, we will present to our fellow
Nabi shareholders a majority slate of proposed replacement directors whom we
believe are far superior to the directors we will seek to remove. Importantly,
the nominees we will ask Nabi's shareholders to endorse will have only one
objective - to capitalize on the enormous and escalating interest in, and
investment dollars dedicated to, all of the areas in which Nabi currently
participates - for the direct benefit of all Nabi shareholders.


Sincerely,

/s/ Daniel S. Loeb

Daniel S. Loeb


                                      -2-